The hypromellose monograph will be incorporated into and become official with the second supplement to usp 38nf 33. Benecel directly compressible hypromellose hpmc substitution type grade weight average molecular weight solution concentration nominal viscosity mpasa hypromellose 2208 k types k4m ph dc1 400,000 2% 2,7005,040 k15m ph dc1 575,000 2%,50025,200 k100m ph. Msds remove sources of ignition near the spillage area environmental precautions. Goniovisc eye lubricant hypromellose ophthalmic solution, usp. View detailed export data, price, monthly trends, major exporting countries, major ports of hypromellose. Hypromellose indication ocular lubricant, tear replacement 1treatment or prevention of dry eyes where eyes cannot spontaneously close e. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database.
Jun 17, 2019 hypromellose msds pdf page 52 networking basics continued please follow all the instructions in this window. Stir the solution on a magnetic stirrerhot plate, portions of this monograph that are national usp text, and and begin heating at a rate of 25min. Add the sample solution to exactly 50ml of hypromellose water in a beaker. Always use this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you. When you purchase a product from dow, the corresponding safety data sheet sds will be automatically distributed to you from our corporate distribution system.
Material safety data sheethydroxypropyl methyl cellulose. Aqoat was first approved as gastroresistant coating in japan in 1987. When handling, use appropriate personal protective equipment see section 8. Hypromellose has a physicalchemical action and leads to, in an aqueous solution, a reduced surface tension as well as an increased level of viscosity.
Flush with water while holding eyelids open for at least 15 minutes. The viscosity promoting properties of hypromellose prolong the retention time and improve adhesion of synthetic tears to the cornea and conjunctiva. A wide variety of hypromellose msds options are available to you. Material safety data sheet hydroxypropyl methyl cellulose hpmc 1 company and product identification company name. The information and data contained herein are believed to be correct and are given in good faith. Hypromellose phthalate hydroxypropyl methylcellulose phthalate, or hpmcp is a phthalic acid ester of hydroxypropyl methylcellulose. Calculate the percentage of methoxy och sample solution. In the pharmaceutical industry, hypromellose phthalate is used as a coating agent for tablets and granules. Hydroxypropylmethyl cellulose, hydroxypropylmethylcellulose 2910. Dry eyes can occur when the body is unable to produce enough tears. For any questions about the pdg and its processes, please see the pharmacopeial harmonization website or. Follow your doctors orders or the directions on the label. Relevant identified uses of the substance or mixture and uses advised against identified uses laboratory reagent. Contents page preface matrix system selection of metolose grades specifications properties powder solution application related patents 3 45 6 8 10 14 17 2 please note.
Safety data sheet california carb compliant 1 identification product name. Pfizer inc believes that the information contained in this material safety data sheet is. Identification of the substancepreparation and the companyundertaking material name. Hypromellose is sometimes called hydroxypropyl methylcellulose hypromellose ophthalmic for the eyes is used as an eye lubricant to treat dry irritated eyes. The medical term for this condition is keratoconjunctivitis sicca. Mitchell the dow chemical company, midland, mi 48674 introduction hypromellose hpmc is a polymer frequently used in oral solid dosage forms to sustain the release of drugs. Hypromellose, formerly known as hydroxypropylmethylcellulose hpmc, is by far the most commonly employed cellulose ether used in the fabrication of hydrophilic matrices. What you need to know b efore you use hypromellose eye drops 3. Contents page preface designation and structural formula of hpmcp designation, admissions to compendia, chemical name trade name structural formula physicochemical properties 1 real specific gravity 2 apparent density 3 equilibrium moisture content. Pharmaceutical product for the treatment of high cholesterol hyperlipidemia. Weve included the most sought after safety data sheets, and the. Remove contaminated clothing, jewelry, and shoes immediately. Chemical product and company identification product name.
Safety data sheet according to 29cfr19101200 and ghs rev. As a food additive, hypromellose is an emulsifier, thickening and suspending agent. Contents page preface designation and structural formula of hpmcp designation, admissions to compendia, chemical name. Proprietary ingredients indicated as hazardous have been assessed under standards for workplace safety. Hypromellose inn, short for hydroxypropyl methylcellulose hpmc, is a semisynthetic, inert, viscoelastic polymer used as eye drops, as well as an excipient and controlleddelivery component in oral medicaments, found in a variety of commercial products. Hypromellose medicinal forms bnf content published by nice. In case of small spills, flush the remaining material with plenty of water in case of large spills, vacuum or scrap up as much as possible then flush the remaining do not wash into drain methods for containment. Hpmcas was developed as an enteric film coating because it is insoluble in acidic gastric fluid. Gonak hypromellose ophthalmic demulcent solution, 2. Safety data sheet hydroxypropylmethyl cellulose viscocity. Hypromellose has familiar, wellunderstood properties of the available range of cellulosic controlledrelease agents, hypromellose is the most widely used. Its advantages over methylcellulose are that mucilages of hypromellose have greater clarity and fewer undispersed fibres are usually present.
Download msds material safety data sheet of dextran mw 10,000. Cercla hazardous substance and reportable quantity. Documents coa, msds and technical specifications are available for all our products. Material safety data sheet doc notcteres100 14 version. Aquasolve hpmcas is used as a solid dispersion polymer for bioavailability enhancement.
Since then, aqoat has also been approved in europe and the united states for a variety of applications such as filmcoating in aqueous mediums, filmcoating in organic medium, dry coating or solid dispersions. Handling and storage handling advice on safe handling. Hypromellose ophthalmic is also used during certain eye surgeries to help maintain the shape of the eye, and to protect the tissues of the eye from injury during the procedure. Gon iovisc hypromellose ophthalmic demulcent solution, 2. Msds document numbern000 revision dated 03 sept 96 in an emergency, call chemtrec at 8004249300 us toll free or 7035273887 contents. About 3% of these are electronics chemicals, 26% are leather auxiliary agents, and 31% are water treatment chemicals. Empirical modeling of tablets containing hypromellose. Jun 18, 2018 hypromellose is a soothing emollient solution with properties and uses similar to those of methylcellulose. Ac412160000, ac412165000, ac412170000, ac412175000 synonyms. Lubricant, penetrant, drives out moisture, removes and protects surfaces from corrosion restrictions on use. Hypromellose propylene glycol ether of methylcellulose methocel 310 series products methocel a series products methocel f series products methocel k series products cas no. The following information includes only the average doses of hypromellose.
Hypromellose complete drug information, side effects and. Material safety data sheet msds for antibodies cell signaling. Methocel k100m premium hydroxypropyl methylcellulose. Benecel directly compressible hypromellose hpmc substitution type grade weight average molecular weight solution concentration nominal viscosity mpasa hypromellose 2208 k types k4m ph dc1 400,000 2% 2,7005,040 k15m ph dc1 575,000 2%,50025,200 k100m ph dc1 1,000,000 2% 75,000140,000. Official may 1, 2019 stage 4 harmonization 3 usp change to. Aquasolve hypromellose acetate succinate hpmcas versatile cellulosi nteri coatin polymers aquasolve hpmcas is a mixture of acetic acid and monosuccinic acid esters of hydroxypropylmethyl cellulose. Transfer a quantity of hypromellose 3 in the portion of hypromellose taken. Find patient medical information for lubricant eye drops hypromellose ophthalmic eye on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. If you are uncertain about any of the information, consult your doctor or pharmacist. Using dow excipients for controlled release of drugs in. Hypromellose, or hydroxypropyl methylcellulose say that five times fast, is a bit unique. Authentication select open system to communicate the key across the network.
To download, check the box beside the desired documents and click the download button. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Aquasolve hypromellose acetate succinate hpmcas versatile pharmaceutical polymers for improved solubility aquasolve hpmcas is a mixture of acetic acid and monosuccinic acid esters of hydroxypropylmethylcellulose. Hypromellose 9004653 not listed not listed polysorbate 80 9005656 not listed not listed ferric oxide yellow 51274001 2570985 not listed. The dose of hypromellose will be different for different patients. Hypromellose is a soothing emollient solution with properties and uses similar to those of methylcellulose. Recommend splash protection or chemical safety glasses contaminated equipment.
Hypromellose, short for hydroxypropyl methylcellulose hpmc, is a semisynthetic, inert, viscoelastic polymer used as eye drops, as well as an excipient and controlleddelivery component in oral medicaments, found in a variety of commercial products as a food additive, hypromellose is an emulsifier, thickening and suspending agent, and an alternative to animal gelatin. Nitrogen msds material safety data sheet for nitrogen n2 reference. Aquasolve hypromellose acetate succinate hpmcas gradea weight average molecular weight nominal viscosity mpas b l 114,700 2. Find patient medical information for hypromellose on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Hydroxypropyl methylcellulose phthalate catalog numbers. Slowrelease control agent used in 1080% concentration. Certificate of analysis coa specification sheet pdf similar products.
Goniovisc ophthalmic lubricant hypromellose 2910 4000 mpa. Wash with soap or mild detergent and large amounts of water until no evidence of chemical remains at least 15 20 minutes. Hypromellose meets usp testing specifications sigmaaldrich. Hypromellose provides the release of a drug in a controlled manner, effectively increasing the duration of release of a drug to prolong its therapeutic effect. Hypromellose 9004653 not listed not listed lactose monohydrate 64044515 not listed not listed triacetin 102761 2030519 not listed additional information. Micronized colestipol hydrochloride tablets trade name. This product is a drug regulated by the food and drug administration fda, and is not regulated by tsca. Propylene glycol ether of methylcellulose modified cellulose. Hypromellose ophthalmic advanced patient information. This document has been prepared in accordance with standards for workplace safety, which require the inclusion of all known hazards of the active. Hypromellose 9004653 not listed not listed povidone 9003398 not listed not listed additional information.
It dissolves in cold water giving a colloidal solution. How to use artificial tears hypromellose 1 % eye drops. Empirical modeling of tablets containing hypromellose t. Sigmaaldrich offers a number of hypromellose products. Methocel e4m hypromellose 2910 usp encore scientific. Hypromellose is simply artificial tears that alleviate irritated or dry eyes. Chemistry of methocel cellulose ethers 1 the former official monograph name of hypromellose was hydroxypropyl methylcellulose or hpmc. If your dose is different, do not change it unless your doctor tells you to do so.